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The final proposed mechanism of RBC vasodilation from the existence of nitrite may be the reduction of nitrite to NO by Hb. Brooks initially researched the nitrite Hb conversation in 1937 and this get the job done was afterwards extended by Doyle in 1981 (Brooks, 1937; Doyle et al., 1981). Nitrite reacts with deoxygenated Hb to type metHb and NO (B